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Progress Report: Structural studies of DUX4-DNA interaction

Hideki Aihara PhD provides an update on his research into the structure of the Dux4 homeodomains in complex with DNA.
by Hideki Aihara PhD See grant Structural studies of DUX4-DNA interaction The aims for this research are to both determine the structure of DUX4 homeodomains-DNA complex using … http://fshfriends.com/blog/progress-report-structural-studies-dux4-dna-interaction/

Progress Report: FSHD myofibers cultured from human xenografts

Dr. Robert Bloch provides an update on his research into xenografting.
by Robert J Bloch PhD See grant: FSHD myofibers cultured from human xenografts Our research is devoted to creating mice that have human skeletal muscles, and then using them to… http://fshfriends.com/blog/progress-report-fshd-myofibers-cultured-human-xenografts/

Progress Report: Xenotransplanation of Human Muscle

Update from Dr. Maura Parker on optimizing expansion of human muscle stem cells for transplant into mice.
The long-term goal of my work is to expand human muscle progenitor cells in culture, and transplant these cells into a mouse muscle in order to replace that muscle with a human FS… http://fshfriends.com/blog/progress-report-xenotransplanation-human-muscle/

Progress Report: RNA-mediaed Epigenetic Silencing of D4Z4 repeats

Update by Jong Won Lim, postdoctoral fellow.
Final Report for grant: RNA-mediated Epigenetic Silencing of D4Z4 repeats: Implications for targeted therapy for FSHD Jong Won Lim, postdoctoral fellow Mentors: Galina Filip… http://fshfriends.com/blog/progress-report-rna-mediaed-epigenetic-silencing-d4z4-repeats/

Progress Report: Targeting DUX4 in the 4qD4Z4 repeat array in FSHD

Jong Won Lim, postdoctoral fellow, provides an update on his fellowship.
by Jong Won Lim, postdoctoral fellow Mentors: Galina Filippova, PhD and Stephen Tapscott, MD, PhD See grant Targeting Epigenetic Silencing of the 4qD4Z4 repeat array in FSHD My… http://fshfriends.com/blog/progress-report-targeting-dux4-4qd4z4-repeat-array-fshd/

Progress Report: Targeting Epigenetic Silencing of the 4qD4Z4 repeat array in FSHD

Jong Won Lim, postdoctoral fellow, provides an update on his fellowship.
by Jong Won Lim, postdoctoral fellow Mentors: Galina Filippova, PhD and Stephen Tapscott, MD, PhD See grant Targeting Epigenetic Silencing of the 4qD4Z4 repeat array in FSHD My… http://fshfriends.com/blog/progress-report-targeting-epigenetic-silencing-4qd4z4-repeat-array-fshd/

Progress Report: Targeting Epigenetic Silencing of the 4qD4Z4 repeat array in FSHD

Jong-Won Lim progress report.
by Jong Won Lim, postdoctoral fellow Mentors: Galina Filippova, PhD and Stephen Tapscott, MD, PhD See grant Targeting Epigenetic Silencing of the 4qD4Z4 repeat array in FSHD A. … http://fshfriends.com/blog/progress-report-targeting-epigene/

Progress Report: FSHD Related Defects in Human Myogenesis

Miller & Tapscott provide a first year summary of progress.
Miller-Tapscott First Year Summary of FSHD research progress. Gene expression profiling of cells from FSHD muscle biopsies suggests an intriguing hypothesis for the pathophysio… http://fshfriends.com/blog/progress-report-fshd-related-defects-human-myogenesis/